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KMID : 0378019680110050061
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New Medical Journal
1968 Volume.11 No. 5 p.61 ~ p.64
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Influence of Hyoscine-N-butylbromide on visualiation of the upper uriuary track by intraveous pyelograbhy
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Abstract
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Influence of Hyoscine-N-butylbromide on visualiation of the upper urivary tract by intraveous pyelograbhy
Jae Choon Cho, Kee Soo Kim.
Department of Urology, Catholic Medical College
Seoul, Korea
The intravenous pyelography is a valuable diagnostic procedure in urological studies. There are four kinds of methods in the visualization of the upper urinary tract: Retrograde pyelography, minute sequence pyelography, antegrade pyelography and intravenous pyelography. Each procedure has its own advantages depending i on the purpose required. In the intravenous pyelography every effort should be made to protect expelling of the radiopaque medium from the renal pelvis into the bladder. The compression exerted on the abdomen around the lower ureters and the Trendelenburg gposition of the table are the choice of methods for this intravebut those are uncomfortable prodecures for the patient even though they are as a routine used in the purpose nous pyelography.
Urine and other contents in the renal pelvis and ureters are drained into the bladder by ureteral peristalsis which is controled by parasympathetic nerves. So far no parasympatholytic agents such as atropine, scopolamine and other similar drugs were found to inhibit the ureteral peristalsis.
C.H. Boehringer Sohn have synthesized Hyoscine-N-butylbromide from scopolamine in their laboratory. Helmut Wick in 1951 reported by experiments Hyoscine-N-butylbromide to be a parasympathetic ganglion blocking agent which inhibits spasms of the smooth muscles and peristalsis in the `gast-ro-intestinal tract, bronchus, kindney, ureters, bladder and uterus.
The purpose of this study is to observe the influence of Hyoscine-N-butylbromide on ureteral spasms and the size of the kidney by intravenous pyelography. The authors choose 30 patients whose urography showed a spastic ureteral narrowing and a kinking of the ureter. Each patient was given 2 ml of Hyoscine-N-butylbromide intramusculary 30 minutes before intravenous pyelography was taken without compression on the lower abdomen and without changing of the patient´s position.
The results obtained were as follows:
1. Spastic ureteral narrowing due to increased ureteral peristalsis subsided by injection of Hyoscine-N-butylbromide on I.V.P.
2. Hyoscine-N-butylbromide was helpful to visusalize the upper urinary tract in the I.V.P. in spine positionl without compression of the lower abdomen and/or by tilting the table.
3. The size of the kidney was enlarged by 1.0 cmX 1.5 cm and caliber of the ureter was also enlarged by 3cm following an injection of Hyoscine-N-butylbromide for I.V.P.
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